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6px;background:var(--surface-2);color:var(--text-secondary);border:.5px solid var(--border);border-radius:var(--radius-ctl);cursor:pointer;transition:border-color .12s ease,background .12s ease,transform .08s ease}@media (hover: hover){.lig-box:hover{border-color:var(--accent-500);background:var(--surface-1);color:var(--accent-700)}}.lig-box:active{transform:scale(.96)}.lig-thumb{display:flex;align-items:center;justify-content:center;width:100%;height:62px;color:var(--text-secondary)}@media (hover: hover){.lig-box:hover .lig-thumb{color:var(--accent-700)}}.lig-thumb-svg{display:block;width:100%;height:100%}.lig-thumb-svg svg{width:100%;height:100%}.lig-thumb-wait{display:block;height:62px}.lig-box-name{font-family:var(--mono);font-size:var(--text-caption);font-weight:500;color:var(--text-primary)}@media (max-width: 820px){.input-row{flex-direction:column}.ligand-library{flex:none;width:100%}.lig-reel{flex:none;height:min(260px,50vh)}.lig-reel-track{grid-template-columns:repeat(auto-fill,minmax(100px,1fr))}}@media (max-width: 768px){main{padding:14px 12px}main.with-scene{max-width:100%}header{padding:12px 14px;flex-wrap:wrap;gap:10px 12px}.brand-row{gap:10px}.app-logo{height:52px}.wordmark{font-size:1.375rem}.tagline{font-size:var(--text-caption)}.header-right{gap:12px}.freilab-logo{height:26px}.card{padding:14px;margin-bottom:14px}#viewer,.viewer,.scene-wrap{height:min(58vh,340px)}.scene-wrap,#viewer,.viewer,.viewer-grid,.viewer-grid-canvas{touch-action:none}.primary,.ghost,.toggle-btn,select{min-height:40px}.result-item{display:flex;flex-wrap:wrap;align-items:center;column-gap:10px;row-gap:6px}.result-item .name{flex:1 1 60%;min-width:0}.result-item .result-actions{flex:1 1 100%;justify-content:flex-end}}@media (max-width: 480px){main{padding:12px 10px}.card{padding:12px}.app-logo{height:44px}.wordmark{font-size:1.25rem}#viewer,.viewer,.scene-wrap{height:min(52vh,300px)}.chip-smiles{max-width:110px}.scene-panel .palette-chip{font-size:var(--text-caption)}}.tour-root{position:fixed;top:0;right:0;bottom:0;left:0;z-index:1000;pointer-events:none}.tour-blocker{position:fixed;top:0;right:0;bottom:0;left:0;background:transparent;pointer-events:auto}.tour-blocker.dim{background:#060c128c}.tour-blocker.pass{pointer-events:none}.tour-highlight{position:fixed;border-radius:10px;pointer-events:none;border:2px solid var(--accent-bright);box-shadow:0 0 0 9999px #060c128c,0 0 0 4px var(--accent-50);transition:top .22s ease,left .22s ease,width .22s ease,height .22s ease}.tour-tooltip{position:fixed;z-index:1002;box-sizing:border-box;pointer-events:auto;width:min(460px,calc(100vw - 32px));background:var(--surface-1);color:var(--text-primary);border:.5px solid var(--border-strong);border-radius:var(--radius-card);box-shadow:var(--shadow-pop);padding:16px 18px 13px}.tour-tooltip.free{left:50%;transform:translate(-50%)}.tour-tooltip.docked{bottom:28px;left:50%;transform:translate(-50%)}.tour-wait{display:inline-flex;align-items:center;gap:8px;font-size:var(--text-ui);font-weight:500;color:var(--accent-500)}.tour-wait-dot{width:9px;height:9px;border-radius:50%;background:var(--accent-bright);animation:tour-wait-pulse 1.2s ease-out infinite}@keyframes tour-wait-pulse{0%{box-shadow:0 0 #5a5ad880}to{box-shadow:0 0 0 9px #5a5ad800}}.tour-count{font-size:var(--text-caption);color:var(--text-muted);margin-bottom:6px}.tour-title{margin:0 0 6px;font-size:var(--text-heading);font-weight:500;color:var(--text-primary)}.tour-body{margin:0 0 14px;font-size:var(--text-ui);line-height:1.5;color:var(--text-secondary)}.tour-nav{display:flex;align-items:center;justify-content:space-between;gap:8px}.tour-nav-right{display:flex;align-items:center;gap:8px}.tour-btn-wrap{position:relative;display:inline-flex}.toggle-btn.nudge{border-color:var(--accent-500);color:var(--accent-500);font-weight:500;animation:tour-nudge-pulse 1.5s ease-in-out infinite}@keyframes tour-nudge-pulse{0%,to{box-shadow:0 0 #5a5ad859}50%{box-shadow:0 0 0 6px #5a5ad800}}.tour-hint{position:absolute;top:calc(100% + 12px);right:0;z-index:1003;width:max-content;max-width:250px;display:flex;align-items:flex-start;gap:10px;background:var(--surface-1);color:var(--text-primary);border:1px solid var(--accent-500);border-radius:var(--radius-card);font-size:var(--text-ui);line-height:1.4;padding:11px 12px;box-shadow:var(--shadow-pop),0 0 0 4px var(--accent-50);animation:tour-hint-pop .42s cubic-bezier(.2,1.35,.4,1) both}.tour-hint:before{content:"";position:absolute;top:-6px;right:20px;width:11px;height:11px;background:var(--surface-1);border-left:1px solid var(--accent-500);border-top:1px solid var(--accent-500);transform:rotate(45deg)}.tour-hint-icon{flex:none;font-size:18px;line-height:1.2}.tour-hint-text{display:flex;flex-direction:column;gap:1px}.tour-hint-text strong{color:var(--accent-500);font-size:var(--text-ui)}.tour-hint-text span{color:var(--text-secondary)}.tour-hint-x{background:none;border:0;color:var(--text-muted);cursor:pointer;font-size:16px;line-height:1;padding:0 2px;margin-left:2px}@media (hover: hover){.tour-hint-x:hover{color:var(--text-primary)}}@keyframes tour-hint-pop{0%{opacity:0;transform:translateY(-6px) scale(.94)}to{opacity:1;transform:none}}.donor-panel-head{display:flex;align-items:flex-start;justify-content:space-between;gap:12px;margin-bottom:8px}.donor-panel-actions{display:flex;gap:6px;flex:none}.icon-btn{display:inline-flex;align-items:center;justify-content:center;width:28px;height:28px;border-radius:var(--radius-ctl, 8px);border:.5px solid var(--border-strong);background:var(--surface-1);color:var(--text-secondary);cursor:pointer;padding:0}@media (hover: hover){.icon-btn:hover{color:var(--text-primary);border-color:var(--accent-500)}}.icon-btn.save{color:var(--success)}@media (hover: hover){.icon-btn.save:hover{color:var(--success);border-color:var(--success)}}.chip.custom-isomer{display:inline-flex;align-items:center;gap:5px;margin-top:4px;background:var(--accent-50);color:var(--accent-700);border-color:var(--accent-200);font-size:var(--text-caption);font-weight:500}.chip.custom-isomer .chip-x{background:none;border:0;color:var(--accent-700);cursor:pointer;font-size:14px;line-height:1;padding:0 1px;opacity:.7}@media (hover: hover){.chip.custom-isomer .chip-x:hover{opacity:1}}@media (prefers-reduced-motion: reduce){.tour-highlight,.act-col:before,.table-scroll-wrap:before{transition:none}.toggle-btn.nudge,.tour-wait-dot,.tour-hint{animation:none}.adv-tip,.floating-logo{transform:none;transition:opacity .12s ease}.lig-box{transition:border-color .12s ease,background .12s ease}.lig-box:active{transform:none}}.flip-counter{display:flex;align-items:center;justify-content:center;flex-wrap:wrap;gap:6px 10px;margin-bottom:10px;padding-inline:16px}.flip-board{display:inline-flex;gap:6px;--flap-h: 22px}.flip-group{display:inline-flex;gap:2px}.flap{position:relative;width:calc(var(--flap-h) * .68);height:var(--flap-h);border-radius:3px;perspective:calc(var(--flap-h) * 6);background:var(--flap-bg);color:var(--flap-fg);font-family:var(--mono);font-weight:500;font-size:calc(var(--flap-h) * .7);font-variant-numeric:tabular-nums;box-shadow:var(--shadow-pop-sm)}.flap:after{content:"";position:absolute;left:0;right:0;top:calc(50% - .5px);height:1px;background:var(--flap-seam);opacity:.45;z-index:3}.flap-half,.flap-leaf{position:absolute;left:0;right:0;height:50%;overflow:hidden;background:var(--flap-bg);backface-visibility:hidden}.flap-half>span,.flap-leaf>span{position:absolute;left:0;right:0;height:200%;display:flex;align-items:center;justify-content:center;line-height:1}.flap-top{top:0;border-radius:3px 3px 0 0;transform-origin:50% 100%}.flap-top>span{top:0}.flap-bot{bottom:0;border-radius:0 0 3px 3px;transform-origin:50% 0%}.flap-bot>span{bottom:0}.flap-leaf{z-index:2}.flap-fall{animation:flap-fall 45ms ease-in both}.flap-land{animation:flap-land 45ms ease-out 45ms both}@keyframes flap-fall{0%{transform:rotateX(0)}to{transform:rotateX(-90deg)}}@keyframes flap-land{0%{transform:rotateX(90deg)}to{transform:rotateX(0)}}@media (prefers-reduced-motion: reduce){.flap-fall,.flap-land{animation-duration:1ms;animation-delay:0ms}}